Distinctive Effects of Fullerene C<sub>60</sub> and Fullerenol C<sub>60</sub>(OH)<sub>24</sub> Nanoparticles on Histological, Molecular and Behavioral Hallmarks of Alzheimer's Disease in APPswe/PS1E9 Mice.

Although no significant group differences were found, a strong trend toward reduced sucrose preference was noted in WT mice treated with C 60 ( p = 0.0579, Tukey’s test).

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There was a notable trend indicating a treatment effect on the density of the smallest plaques (<100 μm 2 ) in the hippocampus (F = 3.442, p = 0.0608, one-way ANOVA, Figure 5 D) and a significant treatment effect in the thalamus (F = 5.736, p = 0.0151, one-way ANOVA, Figure 5 G).

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In contrast, C 60 (OH) 24 -treated APP/PS1 mice showed a trend towards downregulated GFAP activation compared to C 60 (OH) 24 -treated WT mice.

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The data suggest a trend toward restored Cldn5 expression levels in fullerenol-treated transgenic mice, although this effect did not reach statistical significance ( Figure 7 E).

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