Risk factors for persistent hypertension in primary aldosteronism after surgery: a systematic review and meta-analysis.

Front Physiol · 2025 · PMC12367742 · PMID 40852460

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

approached significanceP = 0.06so close (0.05 < p ≤ 0.1)

DBP approached significance (P = 0.06), likely limited by small sample sizes and measurement heterogeneity (ambulatory vs. office BP) ( De Bhailis and Kalra, 2022 ; Chen et al., 2021 ).

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showed a trendP = 0.06so close (0.05 < p ≤ 0.1)

However, DBP showed a trend toward association with postoperative hypertension (DBP: OR = 1.17, 95% CI: 0.99–1.38, P = 0.06, I 2 = 30%), approaching but not meeting our predefined significance threshold (P < 0.05).

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near-significantno p-value reported

This near-significant result may reflect limited statistical power due to heterogeneous DBP measurement protocols across studies or a true but modest effect requiring larger samples to confirm.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.