Inhibition of AhR improves cortical bone and skeletal muscle function via preservation of neuromuscular junctions.

However, higher-resolution micro-computed tomography (microCT) measurements of cortical bone in the midshaft of the femur demonstrated that BAY-treated mice had a subtle but significantly greater cortical bone volume fraction ( P = 0.0286; Figure 5B ) as compared with VEH-treated mice, resulting from a strong trend for greater cortical bone volume ( P = 0.0583; Figure 5C ) without an impact on cortical bone tissue volume ( P = 0.2807; Figure 5D ).

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Interestingly, BAY treatment promoted a relative decrease in weight of the fast-twitch extensor digitorum longus (EDL) and a mild trend for decreasing the weight of the quadriceps ( Figure 2, G and H ).

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Gene Ontology analyses revealed 10 pathways differentially regulated between the 2 groups, with 7 additional pathways that approached significance ( Supplemental Table 4 and Figure 8C ); “Circadian Entrainment” represented the highest enrichment score.

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While cortical bone thickness was not affected by treatment ( P treatment = 0.2926; Figure 7D ), mice treated with CH-223191 showed a trend for increased polar moment of inertia ( P treatment = 0.0823; Figure 7E ).

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