Prediction and effect on relapse of natural killer cell alloreactivity based on KIR-HLA interactions in pediatric haploidentical transplantation with anti-thymoglobulin.

Front Immunol · 2025 · PMC12417149 · PMID 40934005

Europe PMC DOI

hedged sentences

0.0500

closest p · 1.0× alpha

0.4950

boldest claim

The sentences

a significant trendp > 0.05actually significant

However, our analysis did not reveal a significant trend toward a lower CIR for patients with Tel- or Cen-Bx grafts compared with Cen- or Tel-AA donors (p > 0.05) ( Table 2 ).

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showed a trendp = 0.061so close (0.05 < p ≤ 0.1)

Although the strong inhibitory KIR3DL1/Bw4 combination showed a trend toward reduced relapse incidence in univariate analysis ( Table 3 , p = 0.061), this association was not confirmed in the final multivariate model, consistent with recent reports ( 9 , 10 , 17 ).

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did not reach statistical significancep = 0.495not close (p > 0.1)

In terms of KIR2DS1–C2 educational interactions, patients exhibiting activating KIR–HLA interactions had a higher 5-year CIR (0.352; 95% CI, 0.179–0.530; n = 36) compared with those without predicted alloreactivity (0.274; 95% CI, 0.190–0.365; n = 151), although this difference did not reach statistical significance (p = 0.495) ( Table 2 ).

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