Barely Significant
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Outcomes of autologous bone grafts <i>vs</i> bone substitutes in tibial plateau fractures: A meta-analysis.

World J Orthop · 2025 · PMC12444308 · PMID 40979149

Europe PMCDOI
3
hedged sentences
0.0800
closest p · 1.6× alpha
0.0900
boldest claim

The sentences

did not reach statistical significanceP value = 0.08so close (0.05 < p ≤ 0.1)
Impact of methodological factors When stratifying by publication period, more recent studies (2016 and above) reported a lower risk of secondary collapse with bone substitutes (RR = 0.98, 95%CI: 0.73, 1.31) compared to earlier studies (2008-2015), which favored autografts (RR = 2.01, 95%CI: 0.98, 4.11), despite that this difference did not reach statistical significance ( P value = 0.08).

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approached significanceP value = 0.09so close (0.05 < p ≤ 0.1)
The test for subgroup differences approached significance ( P value = 0.09).

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showed a trendno p-value reported
For secondary collapse rates, Western studies (three studies, 295 patients) demonstrated a significantly higher risk with autografts compared to bone substitutes (RR = 1.45, 95%CI: 1.07, 1.97; P value = 0.02), while the single Asian study (74 patients) showed a trend in the opposite direction, however this was not statistically significant (RR = 0.56, 95%CI: 0.21, 1.50; P value = 0.25).

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