World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (WCO-IOF-ESCEO 2025).

A weakly significant association between BMI categories and frailty was observed (p = 0.040).

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However, correlations between % Δ uc-BGP and Tibial parameters, including Tibial Total Volumetric BMD (r = -0.08), Failure Load (r = − 0.11), and Stiffness (r = − 0.11), did not reach statistical significance (p > 0.05) ( Fig. 2 ).

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P1NP levels significantly differed at M + 3 between the Dmab → Dmab and Dmab → Dmab + Romo groups (+ 24.4 ng/mL, SE 12.6; p = 0.033), with a trend toward significance at M + 6 (+ 13.4 ng/mL, SE 7.7; p = 0.057).

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Although this association showed a trend towards significance, it did not reach statistical significance (p = 0.071).

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At lumbar spine M + 12, the Dmab → Dmab + Romo group showed a trend toward greater BMD increases compared to the Dmab → Dmab group (+ 3.2%, SE 4.4; p = 0.074), as did the Naïve → Romo group compared to Dmab → Dmab (+ 4.4%, SE 3.7; p = 0.064).

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A borderline significant difference (p = 0.08) was noted for hip fracture risk, with a higher risk in the "higher platelet count group".

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Despite the lack of statistical significance, osteoanabolic treatment was associated with a better preservation of HGS and a slight trend toward greater mobility recovery.

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VCS also increased the odds of sustaining a fracture, but this did not achieve significance. Discussion : In this young and equally sex-distributed cohort of PD patients, fracture incidence was high, and its risk increased with age, PD vintage and PTH levels ≤ 150 pg/mL.

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We added HBA1C to the final model and found that elevated HbA1c levels reduced the odds of low BMD with borderline significance (OR: 0.746 95% CI 0.557–1.00, p- value 0.05).

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Results : There is a highly significant difference between the values of the studied parameters (VAS, SRM and SF-MOS) of the subjects in the study group and those in the control group, those in the study group having higher average values than the others for VAS (p = 0.00000079 < 0.001) and SRM (p = 0.000016 < 0.001), but lower than the others (p = 0.000000014 < 0.001) for SF-MOS.

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In the development or progression of diabetic macroangiopathy, raised high shear blood viscosity with decreased erythrocyte deformability and elevated low shear blood viscosity with erythrocyte aggregation may be significant and perhaps treatable variables.

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Results : From 1990 to 2021, the KOA burden still showed an increasing trend globally, faster in females than males; the 35–39 years population has faster KOA symptoms, and 45–49 years have faster prevalence and DALYs.

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Conclusion : There were small but significant associations between longitudinal change in SH levels and decreases in lean mass and physical performance, supporting that the development of sarcopenia in older men is related to changes in total testosterone, with some associations with SHBG, E1 and E2.

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