The abscopal effect in metastatic lung cancer: a retrospective analysis of combined radiotherapy and immunotherapy.

Clin Exp Metastasis · 2025 · PMC12474601 · PMID 41003851

Europe PMC DOI

hedged sentences

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closest p · 1.6× alpha

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boldest claim

The sentences

a near-significant trendp = 0.08so close (0.05 < p ≤ 0.1)

RT to the cerebrum showed a trend toward worse PFS (HR = 1.63, 95% CI: 0.93–2.84, p = 0.09), while RT to the primary tumor site showed a near-significant trend toward improved PFS (HR = 0.6, 95% CI: 0.33–1.06, p = 0.08).

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showed a trendp = 0.08so close (0.05 < p ≤ 0.1)

TP53 mutations showed a trend towards worse OS (HR = 1.92, 95% CI: 0.92–4.01, p = 0.08).

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did not reach statistical significanceno p-value reported

Other variables—including sex, histology, PD-L1 expression, radiation dose, age, and immunotherapy—did not reach statistical significance (see Table 2 ).

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