Spatial signatures for predicting immunotherapy outcomes using multi-omics in non-small cell lung cancer.

Nat Genet · 2025 · PMC12513832 · PMID 41073787

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

showed a trendP = 0.06so close (0.05 < p ≤ 0.1)

Although the resistance model showed a trend toward worse PFS (HR = 2.3, P = 0.06), significance was not reached.

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near-significantP = 0.06so close (0.05 < p ≤ 0.1)

M2 macrophages showed near-significant interaction with CD8 T cells ( P = 0.06), highlighting a modulation of cytotoxic responses.

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did not achieve significanceno p-value reported

3d,e ), but did not achieve significance in the validation cohort (Supplementary Fig. 3f ).

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did not reach statistical significanceno p-value reported

These trends were observed across cohorts but did not reach statistical significance after Benjamini–Hochberg (BH) adjustment.

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