Effects of pentoxifylline in patients with chronic Chagas cardiomyopathy: A randomized, double-blind, controlled pilot trial.

However, the comparative analysis between the groups did not reach statistical significance (p = 0.2).

also in 111,027 other papers

Discussion The main findings of this study testing the effect of use of PTX in patients with CCC showed a trend toward reducing serum levels of pro-inflammatory cytokines, such as IL-6 and TNF-α, and increasing serum levels of the anti-inflammatory cytokine IL-10.

also in 53,322 other papers

Effects of pentoxifylline on serum cytokines As pointed out above, the serum cytokine levels presented in Table 2 , demonstrate that patients treated with PTX showed a strong trend toward an increase in IL-10, an anti-inflammatory cytokine, suggesting a favorable effect of the drug in modulating the inflammatory mechanisms present in the chronic phase of the disease.

also in 5,725 other papers