Genome-wide association and DNA methylation analyses of SSRI treatment response in major depressive disorder.

In addition, WGCNA identified a co-methylation module that showed a trend-level association with SSRI response after adjustment for clinical covariates, and hub genes within this module were functionally linked to neuronal signaling in PPI network analysis.

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None of the CpGs remained statistically significant after multiple testing correction; however, nominally significant CpGs are presented for reference.

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While one fold showed nominal significance, the overall cross-validated association did not reach statistical significance, suggesting that the predictive ability of the PRS in our cohort is limited and not robust.

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