Frequency of Microvascular Pathology and Hippocampal Atrophy on Magnetic Resonance Imaging in a Community Study of Alzheimer's Disease with Blood-Based Biomarkers.

ANN NEUROL 2025;98:1027–1043 Although WMH volume showed a nominally significant association with hippocampal volume ( p = 0.04) in the P‐tau181‐based BM‐CTL group, this did not remain significant after correction for multiple comparisons.

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Although APOE‐ε4 BM+ individuals tended to have larger WMH volumes than BM− individuals, this difference did not reach statistical significance.

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WMHs showed a trend toward larger volume in APOE ‐ ε 4 (BM+) compared with APOE ‐ ε 4 (BM−), but no significant association was found due to the small sample size.

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