Effect of Atogepant on Sleep Quality and Sleep-Related Adverse Events in Adult Patients with Migraine: A Prospective Observational 12-Week Study.

CNS Drugs · 2025 · PMC12602620 · PMID 41073685

Europe PMC DOI

hedged sentences

0.0730

closest p · 1.5× alpha

0.0730

boldest claim

The sentences

approached significancep = 0.073so close (0.05 < p ≤ 0.1)

a possible trendno p-value reported

did not reach statistical significanceno p-value reported

However, time (pre–post treatment) × RR50% interaction approached significance ( F (1,40) = 3.383, p = 0.073), suggesting a possible trend toward greater sleep improvement over time in responders, though this did not reach statistical significance.

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showed a trendno p-value reported

Of note, our study showed a trend suggesting that patients who achieved response status (RR50%) may have experienced better overall sleep quality (according to PSQI score), though this was not statistically confirmed.

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