Impact of surgical interval on DFS and OS Kaplan-Meier survival analysis demonstrated that the short-interval group (neoadjuvant therapy to surgery <6 weeks) exhibited a higher survival probability in OS compared to the long-interval group (≥6 weeks), although the difference did not reach statistical significance (P=0.059) ( Figure 3 ).
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Strategies of neoadjuvant therapy in esophageal cancer: a study on the effects of treatment frequency and surgery interval.
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0.0590
0.0870
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near-significantP=0.087
Regarding perioperative complications, the incidence of anastomotic leakage was 3.85% (3 cases) in the short-term group and 0.56% (1 case) in the long-term group, with a near-significant difference (P=0.087).
The median blood loss was 127 mL in the short-term group and 175 mL in the long-term group (P=0.053), a difference approaching significance, suggesting that a longer surgical interval may be associated with increased operative time and higher blood loss.