Potential sustained benefits of early targeted panretinal photocoagulation in combination with anti-VEGF in macular edema secondary to retinal vein occlusion: 48-month results of a retrospective comparative study.

Combined therapy showed a trend toward improved anatomical outcomes, particularly in patients with baseline ischemic index (IsI) ≥ 15%.

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In conclusion, while our study suggests a potential trend toward improved anatomical outcomes with combined early PRP and anti-VEGF therapy, particularly in severe ischemic RVO, this benefit did not reach statistical significance and did not reduce the treatment burden.

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This approach revealed a near-significant difference in CRT reduction at 4 years in the IVL group when baseline IsI ≥ 15% (Table 4 ).

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