after ETI therapy showed extensive and highly significant changes in the sinonasal epithelial and immune compartments, indicating broadly attenuated neutrophilic inflammation and improved epithelial remodeling.
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Transcriptomic and functional responses of the cystic fibrosis airway epithelium to CFTR modulator therapy.
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Epithelial cell changes showed a trend toward an increased proportion of ciliated cells from baseline to 6 mo. and no change between 6 mo. and 2 yr. and secretory cell types trended toward a decrease from baseline to 6 mo. and increase from 6 mo. to 2 yr.
Mean qPCR copy number as a metric of overall microbial abundance decreased substantially over the time course, although it did not reach statistical significance ( Figure 6A ).
Only nominally significant associations were detected between gene expression and ppFEV1; however, these include multiple biologically plausible targets.