Loss of cell-autonomously secreted laminin-α2 drives muscle stem cell dysfunction in LAMA2-related muscular dystrophy.

Nat Commun · 2025 · PMC12661008 · PMID 41309582

Europe PMC DOI

hedged sentences

0.0512

closest p · 1.0× alpha

0.0512

boldest claim

The sentences

a strong trendP = 0.0512so close (0.05 < p ≤ 0.1)

While we observed a strong trend towards lower active β1-integrin in dy W / dy W PMs ( P = 0.0512) (Fig.

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did not reach statistical significanceno p-value reported

6 h, i ), though the difference did not reach statistical significance.

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showed a trendno p-value reported

Although variability among samples limited definitive conclusions, each mouse showed a trend towards higher levels of laminin-α2 in the injured TA compared to the uninjured TA at 4 DPI, but not at 10 DPI (Fig.

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