CSF markers of vascular injury correlate with tau and cognitive decline in early Alzheimer's disease.

CSF albumin correlated positively with CSF t‐tau ( r = 0.307 p = 0.007) and p‐tau ( r = 0.326, p = 0.004), but the relationships with QAlb did not reach statistical significance.

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CSF PlGF correlated positively with all three CDR domains and with ADAS‐total and ADAS‐13 scores and negatively with MoCA and approaching significance for MMSE (Figure 4B ).

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CSF VCAM‐1 correlated positively with CSF t‐tau and p‐tau only and approached significance for both CSF Aβ 1‐40 and Aβ 1‐42 in CU controls.

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