Radiotherapy and survival in elderly grade 4 glioma patients: The prognostic value of onco-functional outcome.

Survival advantage of NF–RT showed a a strong trend in both univariate (OS HR = 0.47, 95 % CI 0.28–0.82; p = 0.007) and multivariate models (OS HR = 0.57, 95 % CI 0.33–1.00, 0.051).

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Across all four OFO groups (OFO1-4), patients receiving NF-RT tended to experience a numerically longer PFS than those treated with HF-RT, although the difference did not reach statistical significance in any group ( Fig. 3 ).

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Specifically, significant differences between OFO groups were observed for OS in patients ≥ 60, ≥65, and ≥ 70 years, with a strong trend toward significance in those ≥ 75 years.

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