Immunometabolic profiling in menopausal women with multiple sclerosis: the role of adipokines and hormone therapy.

BMJ Neurol Open · 2025 · PMC12684142 · PMID 41368034

Europe PMC DOI

hedged sentences

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closest p · 1.0× alpha

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boldest claim

The sentences

near-significantp=0.050actually significant

BMI-normalised plasma adipsin positively correlated with LV, serum NfL and GFAP, and showed a near-significant correlation with CSF NfL (ρ=0.67, p=0.050).

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did not reach statistical significanceno p-value reported

A greater proportion of PwMS than HC were classified as postmenopausal; although this difference did not reach statistical significance, a potential confounding effect on baseline comparisons cannot be excluded.

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showed a trendno p-value reported

BMI (ρ=0.48, p=0.06) and the leptin-to-adiponectin ratio (ρ=0.46, p=0.07) showed a trend towards a positive correlation with MSSS.

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