Clinical and Pathological Characteristics and Treatment Implications of <i>BRCA1</i>- and <i>BRCA2</i>-Mutated Breast Cancer in Japanese Patients: A Single-Institution Retrospective Study.

Breast Cancer (Auckl) · 2025 · PMC12701933 · PMID 41399478

Europe PMC DOI

hedged sentences

0.0707

closest p · 1.4× alpha

0.0707

boldest claim

The sentences

approached significanceP = .0707so close (0.05 < p ≤ 0.1)

Lymph node (LN) metastasis rates approached significance ( P = .0707), with BRCA1 BC showing fewer LN metastases (75%) than BRCA2 BC (53.8%).

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approaches statistical significanceno p-value reported

Although this difference approaches statistical significance, it highlights a trend that may influence prognosis and treatment decisions.

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did not reach statistical significanceno p-value reported

Although this trend did not reach statistical significance, it suggests that BRCA2 BC may have a more invasive phenotype.

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showed a trendno p-value reported

Notably, ER-positive BRCA tumors showed a trend toward higher recurrence.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.

Clinical and Pathological Characteristics and Treatment Implications of &lt;i&gt;BRCA1&lt;/i&gt;- and &lt;i&gt;BRCA2&lt;/i&gt;-Mutated Breast Cancer in Japanese Patients: A Single-Institution Retrospective Study.

The sentences

Clinical and Pathological Characteristics and Treatment Implications of <i>BRCA1</i>- and <i>BRCA2</i>-Mutated Breast Cancer in Japanese Patients: A Single-Institution Retrospective Study.