RFX1 Regulates Immune Microenvironment and Predicts Immunotherapy Response in Colon Cancer: A Multi-Omics and Clinical Analysis.

Although a similar negative trend was observed with MSI status, the correlation did not reach statistical significance ( p > 0.05) ( Fig.

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In addition, despite the high correlation between IFNG and CD274, both showed a trend of negative correlation with RFX1, which is consistent with the previous results ( Fig. 5C ).

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Previously, we found that in colon cancer, RFX1 showed a negative trend in correlation with the expression of key chemokines (CXCL9 and CXCL10) that induce the recruitment of CD8 + T cells to the tumor microenvironment.

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