Sez6L2 autoimmunity induces cerebellar ataxia in mice.

J Neuroinflammation · 2025 · PMC12750838 · PMID 41291765

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near-significantno p-value reported

After stimulation with Sez6L2, we observed significant or near-significant populations of CD4 + T cells expressing IFNɣ, TNFα, IL-4, or IL-17 from both H- and M-Sez6L2 immunized mice compared to sham-immunized controls (Fig. 4 C, D).

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did not reach statistical significanceno p-value reported

Although the M-Sez6L2 immunized mice did not reach statistical significance, they also showed a trend for increased foot faults.

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showed a trendno p-value reported

The H-Sez6L2 immunized mice also showed a trend towards spending more time immobile at the 5.5-week timepoint.

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