Harnessing early postoperative MRD and VAF dynamics for precision prognosis in resected colorectal liver metastases.

J Cancer Res Clin Oncol · 2026 · PMC12779790 · PMID 41501499

Europe PMC DOI

hedged sentences

0.0530

closest p · 1.1× alpha

0.0950

boldest claim

The sentences

a borderline significant trendp = 0.053so close (0.05 < p ≤ 0.1)

Interestingly, we found a borderline significant trend ( p = 0.053) in the MRD-negative group, where patients with a higher MaxΔVAF (suggesting a larger drop from a potentially higher preoperative VAF) paradoxically showed a trend towards worse DFS (Fig. 3 A).

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did not reach statistical significancep = 0.095so close (0.05 < p ≤ 0.1)

Although this did not reach statistical significance in our cohort ( p = 0.095), it is biologically plausible.

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showed a trendp = 0.095so close (0.05 < p ≤ 0.1)

Postoperative MRD positivity showed a trend towards association with higher primary tumor T stage ( p = 0.095).

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highly significantno p-value reported

In stark contrast, the 2 week postoperative MRD status demonstrated a strong and highly significant association with DFS in the 63 patients with paired samples (Fig. 1 B).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.