AVN944 Elicits Apoptotic Responses and Impedes Tumorigenic Potential in Ewing's Sarcoma Cells.

Int J Biol Sci · 2026 · PMC12780844 · PMID 41522344

Europe PMC DOI

hedged sentences

0.0610

closest p · 1.2× alpha

0.0610

boldest claim

The sentences

did not reach statistical significancep = 0.061so close (0.05 < p ≤ 0.1)

Although Kaplan-Meier analysis did not reach statistical significance ( p = 0.061), the hazard ratio of 1.5 suggests that high expression of IMPDH2 could be a risk factor for poorer outcomes.

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a clear trendno p-value reported

Our results indicate a clear trend: sarcoma patients with elevated levels of IMPDH2 expression have lower survival rates, reinforcing the enzyme's potential as a therapeutic target.

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showed a trendno p-value reported

Sarcoma patients with high expression of IMPDH2 showed a trend towards poorer overall survival.

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