Potential Utility of Combined Salivary Calprotectin and Anti-Cyclic Citrullinated Peptide in Rheumatoid Arthritis Assessment.

Diagnostics (Basel) · 2025 · PMC12785978 · PMID 41515518

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closest p

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did not reach statistical significancep = 0.071so close (0.05 < p ≤ 0.1)

a clear trendno p-value reported

Although the difference did not reach statistical significance ( p = 0.071), a clear trend was observed in which salivary calprotectin levels increased with the severity of joint damage.

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showed a trendno p-value reported

Interestingly, while salivary anti-CCP correlated with disease activity markers, it showed a trend toward lower radiographic damage.

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