Impact of Brodalumab on Serum Levels of IL-6, IL-17A, IFN-α, IFN-γ, and TNF-α in Patients with Psoriasis Who Failed Treatment with TNF-α Inhibitors.

Int J Mol Sci · 2026 · PMC12786795 · PMID 41516330

Europe PMC DOI

hedged sentences

0.0670

closest p · 1.3× alpha

0.0670

boldest claim

The sentences

showed a trendp = 0.067so close (0.05 < p ≤ 0.1)

However, TNF-α levels showed a trend toward reduction ( p = 0.067), which may reflect prior exposure to TNF-α inhibitors before the initiation of brodalumab.

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near-significantno p-value reported

Nevertheless, the near-significant reduction in TNF-α could indicate secondary immunological effects that merit further investigation.

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did not reach statistical significanceno p-value reported

The results showed a significant increase in IL-17A levels, while changes in IL-6, IFN-α, IFN-γ, and TNF-α did not reach statistical significance.

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