Alzheimer's disease polygenic risk in early- and late-onset Alzheimer's disease.

Alzheimers Dement · 2026 · PMC12802089 · PMID 41532810

Europe PMC DOI

hedged sentences

0.0300

closest p · 0.6× alpha

0.0600

boldest claim

The sentences

nominally significantp = 0.03actually significant

While a nominally significant association of higher PGS with lower CSF Aβ 42/40 was observed ( n = 169, uncorrected p = 0.03), the only other biomarker to show a significant association was SNAP‐25.

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showed a trendp = 0.060so close (0.05 < p ≤ 0.1)

In the LEADS cohort, the model with PGS z showed a trend for predicting increased risk of EOAD (OR = 1.32, p = 0.060).

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did not reach statistical significanceno p-value reported

Within LOAD participants ( r [131] = 0.107, p = 0.224), a trend for positive correlation was observed, though this did not reach statistical significance.

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