Association of TRPV1 genetic variants with cognitive functions in Parkinson disease.

iScience · 2026 · PMC12818065 · PMID 41568154

Europe PMC DOI

hedged sentences

0.0320

closest p · 0.6× alpha

0.0608

boldest claim

The sentences

showed a trendp = 0.032actually significant

However, participants with GG genotypes showed a trend toward better performance in the visuospatial function compared with the AA + AG genotypes ( p = 0.032).

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borderline significantp = 0.0425actually significant

In the Color Trails Test 1, which assesses executive function, although the SNP effect did not reach statistical significance ( p = 0.0608), a borderline significant SNP-diagnosis interaction ( p = 0.0425) was observed, suggesting that the association between rs12936340 and executive performance may differ between the participants with PD and those in the HC group.

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did not reach statistical significancep = 0.0608so close (0.05 < p ≤ 0.1)

In the Color Trails Test 1, which assesses executive function, although the SNP effect did not reach statistical significance ( p = 0.0608), a borderline significant SNP-diagnosis interaction ( p = 0.0425) was observed, suggesting that the association between rs12936340 and executive performance may differ between the participants with PD and those in the HC group.

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borderline significanceno p-value reported

Findings with borderline significance should therefore be interpreted with caution and require replication in larger cohorts.

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nominally significantno p-value reported

Again, the interaction effect was nominally significant but did not survive the Bonferroni correction.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.