Quality of Life of Colorectal Cancer Patients Treated with Chemotherapy.

However, it is worth noting that: In FWB, the proportion of improvement in IG (29%) was higher than in CG (8%), with results approaching significance ( p = 0.05, OR = 4.79, 95% CI: 0.95–24.27, φ = 0.22).

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In a systematic review and meta-analysis, ONS significantly increased body weight and improved nutritional status, while its effect on global QoL was borderline significant (MD +4.01, 95% CI: 0.08–7.94; p = 0.05).

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In ACS, deterioration was less frequent in IG (3%) compared with CG (20%), also reaching borderline significance ( p = 0.07, OR = 0.12, 95% CI: 0.01–1.11, φ = 0.22).

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However, GS4 and GS5 (family acceptance of illness and communication about the disease) showed p -values close to statistical significance ( p = 0.09 and p = 0.06, respectively), suggesting a possible trend toward improvement in these domains.

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These findings suggest that, despite an overall trend toward improvement, some patients experienced deterioration in selected QoL domains, highlighting the importance of individualized therapeutic support.

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Although this change did not reach statistical significance, it may indicate a trend toward improved subjective QoL during the intervention.

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Near-significant trends in GS4 and GS5 (acceptance and communication within family) may reflect gradual increases in perceived social support.

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