Association between low-density lipoprotein and structural changes in the knee joint of patients with symptomatic osteoarthritis is mediated by relative fat mass.

Eur J Med Res · 2026 · PMC12870330 · PMID 41508160

Europe PMC DOI

hedged sentences

0.0830

closest p · 1.7× alpha

0.3120

boldest claim

The sentences

showed a trendP = 0.083so close (0.05 < p ≤ 0.1)

Regarding cartilage volume, LDL showed a trend toward negative association with total cartilage volume (β = −0.197, P = 0.083), while lean mass was strongly positively associated with total cartilage volume (β = 0.092, 95% CI: 0.072 to 0.113, P < 0.001).

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did not reach statistical significanceP = 0.312not close (p > 0.1)

Sex-stratified analyses revealed that the inverse association between RFM and patellar cartilage volume remained significant in females (β = −0.036, P < 0.001, n = 152) but did not reach statistical significance in males (β = −0.028, P = 0.312, n = 20), likely due to limited sample size in the male subgroup.

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failed to reach statistical significanceno p-value reported

This indicates that RFM is a superior predictor of patellar cartilage-volume loss, whereas BMI failed to reach statistical significance for any cartilage-volume measure.

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