The impact of radioligand therapy on prognosis in patients with lung neuroendocrine tumors.

Front Endocrinol (Lausanne) · 2026 · PMC12883361 · PMID 41669545

Europe PMC DOI

hedged sentences

0.0540

closest p · 1.1× alpha

0.2200

boldest claim

The sentences

a strong trendp=0.054so close (0.05 < p ≤ 0.1)

Similarly, median OS was 34 months (95% CI: 14.6–53.3) for monotherapy compared with 80 months (95% CI: 54.3–105.6) for tandem therapy, showing a strong trend towards statistical significance (p=0.054) ( Table 4 , Figure 3 ).

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failed to reach statistical significancep=0.12not close (p > 0.1)

Similarly, median OS was 134 months (95% CI: not estimable) in patients without [1 8 ;F]FDG uptake versus 62 months (95% CI: 8.0–116.0) in patients with FDG-avid disease, which also failed to reach statistical significance (p=0.12) ( Table 4 ).

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a nonsignificant trendp=0.19not close (p > 0.1)

Prior CHT was associated with a nonsignificant trend towards worse OS (HR = 4.3, 95% CI: 0.5–38.2, p=0.19).

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did not reach statistical significancep=0.22not close (p > 0.1)

Patients without [1 8 ;F]FDG-avid disease demonstrated a median PFS of 40 months (95% CI: 18.4–61.6) compared with 16 months (95% CI: 2.6–29.4) in those with FDG-avid tumors; however, this difference did not reach statistical significance (p=0.22).

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