Barely Significant
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Anatomical and Systemic Predictors of Early Response to Subthreshold Micropulse Laser in Diabetic Macular Edema: A Retrospective Cohort Study.

J Clin Med · 2026 · PMC12897633 · PMID 41682636

2
hedged sentences
0.0630
closest p · 1.3× alpha
0.0630
boldest claim

The sentences

showed a trendp = 0.063so close (0.05 < p ≤ 0.1)
Regarding the HbA1c levels, %IRF change showed a trend ( p = 0.063).

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did not reach statistical significancep = 0.085so close (0.05 < p ≤ 0.1)
a negative trendno p-value reported
Diabetes duration showed a negative trend (β = −2.74), suggesting that efficacy may decrease by approximately 2.7% for each additional year of disease duration, although this did not reach statistical significance in the multivariate model ( p = 0.085).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.