Artificial Intelligence-Enabled Integration Suggests TP53 Pathway Alterations as Prognostic Biomarkers in Populations with Disproportionate Health Burdens.

Int J Mol Sci · 2026 · PMC12898670 · PMID 41684025

Europe PMC DOI

hedged sentences

0.0541

closest p · 1.1× alpha

0.0850

boldest claim

The sentences

a near-significant trendp = 0.0541so close (0.05 < p ≤ 0.1)

Among early-onset cases, the median age at diagnosis was slightly higher in FOLFOX-treated patients (42 years; IQR 36–47) compared with those who did not receive FOLFOX (40 years; IQR 34–43), with a near-significant trend ( p = 0.0541).

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approaching borderline significancep = 0.06so close (0.05 < p ≤ 0.1)

Alterations in ATM were more frequent among H/L patients (17.3%) compared with NHW patients (7.9%), a difference approaching borderline significance ( p = 0.06).

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did not reach statistical significancep = 0.085so close (0.05 < p ≤ 0.1)

43 years), a difference that did not reach statistical significance ( p = 0.085).

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highly significantno p-value reported

In Table 2 , for example, comparisons involving larger subgroups yielded highly significant p -values for age, mutation burden, and TMB; however, the absolute effect sizes were modest (e.g., median 3–4 years in age at diagnosis, a difference of 1 mutation, and 0.5 in TMB).

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