Time matters: The prognostic impact of diagnostic delay on survival in primary central nervous system lymphoma-a single-center, retrospective real-world study.

Neurooncol Adv · 2026 · PMC12901676 · PMID 41696494

Europe PMC DOI

hedged sentences

0.0550

closest p · 1.1× alpha

0.0610

boldest claim

The sentences

did not reach statistical significanceP < .055so close (0.05 < p ≤ 0.1)

Patients with a higher tumor burden (>6.9 cm 2 ) tended to have poorer OS compared to those with a lower burden (≤6.9 cm 2 ), though this difference did not reach statistical significance ( P < .055).Variables such as sex, deep brain structure involvement, and CSF protein elevation—previously reported as prognostic markers—were not significant in our cohort ( Supplementary Table S1 ).

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near-significantP < .061so close (0.05 < p ≤ 0.1)

Renal function was also included in the multivariate model due to a near-significant association ( P < .061).

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approaching significanceno p-value reported

Variables demonstrating statistical significance or approaching significance in the univariate analysis were incorporated into a multivariate analysis employing the Cox proportional hazards regression model.

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