Representational differentiation and integration within the hippocampal circuit during naturalistic stimuli.

Commun Biol · 2026 · PMC12916982 · PMID 41606112

Europe PMC DOI

hedged sentences

0.0940

closest p · 1.9× alpha

0.0940

boldest claim

The sentences

did not reach statistical significancep = 0.094so close (0.05 < p ≤ 0.1)

Furthermore, the reverse mediation model, which examined changes in CA3-CA1 geodesic distance as a mediator for the effects of CA1-RSC connectivity on cognition scores, did not reach statistical significance ( p = 0.094, 95% CI = [−0.1, 3.5]), supporting the directionality of our proposed pathway (Table 2 ).

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approaching significanceno p-value reported

near-significantno p-value reported

In this analysis, near-significant mediation effects were observed for connectivity between CA1 and the individual retrosplenial parcels (bilateral Rsp1 and Rsp2), approaching significance ( p ( a × b ) < 0.05, Table S10 ).

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