Bifidobacterium longum and prebiotic interventions restore early-life high-fat/high-sugar diet-induced alterations in feeding behavior in adult mice.

While integrative analysis of pathways restored by the microbiota-targeted interventions did not yield any FDR-significant results in either sex, several nominally significant pathways ( p- value < 0.05) were observed, highlighting potential effects on developmental, signaling, and metabolic processes.

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longum APC1472 showed a trend toward restoring DOPAC synthesis ( t 18.3 = −1.30, q = 0.208, d = 0.53) (Supplementary Fig.

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Tryptophan metabolism was also an enriched pathway in adult male and female mice exposed to the early-life HFHS diet, although it did not reach statistical significance (Fig. 2B , C ).

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