Impact of the surgery to radiotherapy interval on oncological outcomes in squamous cell carcinoma of the oral tongue.

Although the overall DFS patterns between the Early-RT and Late-RT groups were not statistically significant, there was a slight trend favoring earlier RT initiation.

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For patients with locally advanced-stage disease, a longer interval between surgery and RT was associated with a significant trend toward improved DFS.

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The interval between surgery and RT, concurrent chemotherapy, stage, and close margin involvement did not reach statistical significance in this multivariate model for OS.

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This aligns with our findings: in early-stage patients, none received concurrent chemotherapy, and earlier RT showed a trend toward better outcomes; whereas in locally advanced patients, the significant DFS difference was observed only in those who received concurrent chemotherapy.

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