Safety and Effectiveness of Subcutaneous Immunotherapy with a Glutaraldehyde-Polymerized Mite Allergen Extract in Adults and Children with Allergic Rhinitis with or Without Asthma Due to <i>Dermatophagoides</i>.

Changes were significant in adults, with a +29.7-point increase ( p < 0.001), and in the pediatric population, with a +27.3-point increase ( p = 0.031), whereas in children and adolescents, changes did not reach statistical significance ( p = 0.250 and p = 0.051, respectively) ( Figure 2 A).

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Changes followed similar trends in children and adolescents but failed to reach statistical significance ( p = 0.766 and p = 0.622, respectively) ( Figure 1 C).

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Likewise, asthma control showed a trend toward improved control in adults and the pediatric population, with +61.3 and +53.4 percentage-point increases in well-controlled asthma and −29.0 and −6.7 percentage-point decreases in uncontrolled asthma, respectively, but did not reach statistical significance.

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