NGAL and HPV Subtypes in Cervical Carcinoma: Implications for Cancer Progression and Treatment Response.

Curr Issues Mol Biol · 2026 · PMC12939286 · PMID 41751496

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.0700

boldest claim

The sentences

trend toward significancep = 0.06so close (0.05 < p ≤ 0.1)

122 ng/mL, p = 0.06, trend toward significance) and after treatment (179 vs. 123 ng/mL, p = 0.02).

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approached significancep = 0.06so close (0.05 < p ≤ 0.1)

Statistical analysis using independent t -tests revealed that pre-treatment NGAL was greater in inoperable patients, but the difference approached significance: t = 1.93, p = 0.06; and post-treatment NGAL was significantly higher in inoperable patients: t = 2.37, p = 0.02.

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did not reach statistical significancep = 0.07so close (0.05 < p ≤ 0.1)

Results : NGAL levels increased marginally during therapy (from 134 to 144 ng/mL; p = 0.28), but the rise was significant in inoperable patients ( p = 0.02) and increased with advanced FIGO stage, although this did not reach statistical significance ( p = 0.07).

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near-significantno p-value reported

The near-significant post-treatment p -value suggests a biological trend, which could be related to hypoxia, necrosis, or persistent inflammatory responses that are more common in advanced tumors.

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