However, a closer examination of their results reveals a clear trend toward increased risk in PsA patients treated with monoclonal anti-TNFα agents, with a hazard ratio of 1.53 (95% CI, 0.95–2.47, a borderline p -value = 0.077), a finding that did not reach statistical significance, likely due to the limited power of their smaller cohort.
In contrast, demographic factors (age and Arab ethnicity) and several cardiometabolic comorbidities (including obesity, hypertension, IHD, CHF, CVA, and malignancy) did not retain independent associations in the multivariable model; female sex showed a numerically higher odds ratio, although this did not reach statistical significance.
When conducting multivariable analyses, female sex showed a trend toward a higher odds ratio for uveitis, although the estimate did not reach statistical significance.