Atherosclerotic Fibrous Plaques in Women Present ECM Remodeling Linked to TGF-β.

Circ Res · 2026 · PMC12947913 · PMID 41641539

Europe PMC DOI

hedged sentences

0.0880

closest p · 1.8× alpha

0.0880

boldest claim

The sentences

showed a trendP =0.088so close (0.05 < p ≤ 0.1)

did not reach statistical significanceno p-value reported

Female fibrous genes did not reach statistical significance but showed a trend toward higher expression in female SMCs and ECs ( P =0.088 and P =0.085, respectively; Figure S10A ).

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an increasing trendno p-value reported

Analysis of quantitative PCR expression data for EC markers ( PECAM1 , CD34 , VWF , and VE-cadherin ) was found to be downregulated upon TGF-β and TNF-α stimulation compared with control (Figure 4 E), while expression of the mesenchymal markers ( FN1 , Cadherin-2 , and TAGLN ) showed an increasing trend although statistical significance was not achieved (Figure 4 E).

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nominally significantno p-value reported

Therefore, we performed enrichment analyses using nominally significant differentially expressed genes and proteins.

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