Erk3 deletion drives oxidative adaptations in skeletal muscle.

In contrast, the quadriceps muscle, which contains mixed fiber types, displayed a similar upward trend that did not reach statistical significance ( Fig. 4 G,H), while no changes were observed in the oxidative soleus muscle ( Fig. 4 I,J).

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This reduction in body mass was mainly attributable to decreased fat mass and a near-significant trend toward lower lean mass ( Fig. 1 B).

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Unadjusted energy expenditure showed a strong trend toward higher values in HFD-fed Erk3 muscleΔ/Δ mice during night, but not day.

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