Targeting Skeletal Muscle in Duchenne Muscular Dystrophy: Integrating in Silico and Experimental Approaches to Sodium-Glucose Cotransporter-2 Inhibition.

Am J Pathol · 2026 · PMC12975353 · PMID 41391749

Europe PMC DOI

hedged sentences

0.0516

closest p · 1.0× alpha

0.0730

boldest claim

The sentences

near-significantP = 0.0516so close (0.05 < p ≤ 0.1)

This aligned with the near-significant reduction observed in the mouse model ( P = 0.0516).

also in 2,306 other papers

did not reach statistical significanceP = 0.0617so close (0.05 < p ≤ 0.1)

EMPA treatment reduced circulating TGF-β1 levels; however, this reduction did not reach statistical significance ( P = 0.0617) ( Figure 7 G).

also in 111,027 other papers

showed a trendP = 0.0730so close (0.05 < p ≤ 0.1)

Tgfb1 showed a trend toward increased expression in DMD ( P = 0.0730), which was mitigated after EMPA treatment ( P = 0.0516) ( Figure 7 F).

also in 53,322 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.