Changes in brain morphology over the first year in adult mixed-mechanism mild traumatic brain injury: the role of injury severity factors.

Further, volume reductions from admission to 3 months were evident in patients with complicated mTBI in the hippocampus, and the thalamus, while the cerebral WM decrease did not reach statistical significance (p = 0.105, Table 4 , Fig. 4 ).

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Additionally, the observed interaction effect was partly driven by an unexpected increase in hippocampal volume in patients with unobserved LOC that approached significance.

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While no significant group differences were evident at any timepoint, the observed LOC group consistently had larger hippocampal volume, with the difference approaching significance at admission, and smaller differences at 3 and 12 months.

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