2g/m2 Ara-c induced more favorable outcome than 1g/m2 Ara-c in CLAG treatment for refractory or relapsed acute myeloid leukemia without increase toxicity: a multicenter propensity score matching analysis.

Ann Hematol · 2026 · PMC13009106 · PMID 41870589

Europe PMC DOI

hedged sentences

0.0700

closest p · 1.4× alpha

0.0700

boldest claim

The sentences

a strong trend toward significancep = 0.07so close (0.05 < p ≤ 0.1)

13.4%; p = 0.004), with a strong trend toward significance in the PSM cohort (33.9% vs. 13.7%; p = 0.07).

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a clear trendno p-value reported

did not reach statistical significanceno p-value reported

Although the PSM analysis did not reach statistical significance for OS, a clear trend favoring the 2 g/m2 Ara-c dose was observed, suggesting a potential survival benefit with the higher dose in the CLAG regimen for R/R AML.

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