Evaluating Chronic Sex-Specific Changes in Glutamatergic Signaling Markers Following Traumatic Brain Injury.

Int J Mol Sci · 2026 · PMC13026189 · PMID 41898532

Europe PMC DOI

hedged sentences

0.0907

closest p · 1.8× alpha

0.0907

boldest claim

The sentences

approaching significancep = 0.0907so close (0.05 < p ≤ 0.1)

Within the CA1, the effect of injury was approaching significance in terms of integrated density ( p = 0.0907) ( Figure 5 B) but not area fraction ( Figure 5 C).

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showed a trendno p-value reported

Injured males exhibited an increased integrated density of PSD95 fluorescence compared to sham males ( p = 0.0501), whereas females showed a trend toward reduced PSD95 expression that did not reach significance.

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approached significanceno p-value reported

Within the CA1 subregion, GluN2A/PSD95 colocalization showed effects of injury ( p = 0.0575) and sex ( p = 0.0502), which approached significance, indicating a potential injury-driven decrease in colocalization in both sexes following injury.

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