Plasmablast, memory B cell and T follicular helper cell responses after human papillomavirus vaccination: effect of dose number and age.

A trend towards increased Tfh activation was also noted following dose 1, although this did not reach statistical significance.

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Before the administration of the second or third doses, antigen-specific Bmem frequencies showed a trend towards increase, with a robust rise following the subsequent doses (Fig. 4B , C).

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Pairwise comparisons by age showed a clear trend, with activated Tfh cell frequencies being highest in the 4–8-year-olds, intermediate in the 9–14-year-olds and lowest in the 15–26-year-olds.

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