Reduced osteogenic factors and early osteoblast senescence in SOD1(G93A) ALS mouse model.

On the other hand, at P110 SOD1 animals displayed a strong trend ( P = 0.05) toward an inverse correlation between bending stiffness and maximum bending force ( Figure 1F ), indicating a decoupling between these two measures.

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Notably, already at P45, SOD1 bones displayed a trend toward an increased percentage of p16INK4a-positive osteoblasts compared with WT, although they did not reach statistical significance ( P = 0.0698; Figure 6E ).

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In line with these findings, serum C-terminal telopeptide of type I collagen (CTX-I)) showed a trend toward higher values and N-terminal propeptide of type I procollagen (PINP) levels were significantly increased in SOD1 mice at P110, consistent with a high-turnover state at the symptomatic stage ( Supplemental Figure 1, A and B ; supplemental material available online with this article; https://doi.org/10.1172/jci.insight.197475DS1 ).

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