Efficacy of first-line immune checkpoint inhibitors in advanced non-small-cell lung cancer with or without brain metastases: a systematic review and network meta-analysis.

Front Oncol · 2026 · PMC13079038 · PMID 41994648

Europe PMC DOI

hedged sentences

—

closest p

—

boldest claim

The sentences

a strong trendno p-value reported

did not reach statistical significanceno p-value reported

Camre-chemo also showed a strong trend toward prolonged PFS (HR = 0.31, 95% CrI: 0.06–1.66), although this did not reach statistical significance due to wide credible intervals.

also in 5,725 other papers

failed to reach statistical significanceno p-value reported

Given the negligible heterogeneity (P = 0.43, I2 = 1%), a fixed-effects model was deemed appropriate for the analysis in Figure 3A .In this cohort, ICI monotherapy demonstrated a trend toward improved survival compared with chemotherapy alone (HR = 0.65, 95% CrI: 0.39–1.10), though this failed to reach statistical significance.

also in 6,035 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.