Efficacy of GLP-1 receptor agonists in Parkinson's disease: a systematic review and exploratory network meta-analysis of randomized controlled trials.

Neurol Sci · 2026 · PMC13090280 · PMID 41995965

Europe PMC DOI

hedged sentences

0.0571

closest p · 1.1× alpha

0.0571

boldest claim

The sentences

approaching significancep = 0.0571so close (0.05 < p ≤ 0.1)

Substantial heterogeneity was observed (τ2 = 6.69; I2 = 72.4%), with Q approaching significance ( p = 0.0571) (Fig. 4 B).

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did not reach statistical significancep = 0.061so close (0.05 < p ≤ 0.1)

showed a trendno p-value reported

Diarrhoea showed a trend toward increased risk but did not reach statistical significance (RR 1.45, 95% CI 0.98–2.15; p = 0.061; I2 = 0%).

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